Which statement regarding blister formation is correct?

Blister formation is primarily a result of friction, which causes the layers of the skin to separate. This separation occurs between the epidermis (the outer layer of skin) and the dermis (the layer beneath it). When there is consistent rubbing or pressure on a specific area of the skin, fluid accumulates in the space created by this separation, resulting in a blister. Understanding this mechanism is essential for proper blister care and prevention strategies, especially in sports medicine where friction injuries are common. Recognizing that blisters are a protective response to friction can help athletes manage their skin health and improve their performance by addressing potential issues before they escalate.