Which of the following conditions is NOT directly related to an allergic reaction?

Appendicitis is a condition that involves inflammation of the appendix and is not directly related to an allergic reaction. It typically arises due to a blockage, infection, or other non-allergic factors, resulting in abdominal pain, fever, and sometimes nausea. On the other hand, anaphylactic shock and asthma are both immediate responses to allergens, where the body's immune system overreacts to substances like certain foods, insect stings, or medications. Seizures can be triggered by various factors, including allergic reactions in certain cases, particularly when allergens cause neurological symptoms, but they are predominantly associated with other medical conditions. In this context, the key point is that appendicitis does not involve an immune response to allergens, distinguishing it as the correct answer.