What can result from neglecting a blister?

Neglecting a blister can lead to it breaking, which creates an open wound. When a blister is formed, it is typically a protective response of the skin to friction, moisture, or injury, accumulating fluid between the layers of skin. If the blister is not treated or protected, it can become compromised. This can result in the top layer of skin breaking down, leading to an open wound that is more susceptible to infection and further irritation.

In contrast, while a blister may sometimes heal naturally, this is not guaranteed if it is not cared for properly. It is also unlikely to simply form a callus without proper skin conditioning or repeated friction, and the assertion that pain will necessarily cease after a week doesn't take into account the factors influencing recovery or the risk of complications. Therefore, the possibility of a blister breaking and turning into an open wound emphasizes the need for appropriate care and attention to blisters.